Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
This trial is currently recruiting participants
76 locations available for registration
Brief Summary
The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose cotransporter-2 inhibitor (SGLT2i). The study will last about 26 months and may include up to 24 visits.
Eligibility
Age Range
Gender
Healthy Volunteers
Detailed Criteria
Inclusion Criteria: * Have Type 2 Diabetes (T2D) * Have HbA1c ≥ 7.0% (53 millimoles per mole (mmol/mol)) to ≤ 10.5% (91 mmol/mol) * Have been on a stable diabetes treatment consisting of metformin ≥ 1500 milligrams per day (mg/day) with or without SGLT2i during 90 days prior to screening * Are of stable weight for at least 90 days prior to screening * Have a Body Mass Index (BMI) ≥ 25.0 kilograms per meter squared (kg/m\^2) Exclusion Criteria: * Have Type 1 Diabetes (T1D) * Have a history of ketoacidosis or hyperosmolar state or coma within the last 6 months prior to screening * Have a history of severe hypoglycemia or hypoglycemia unawareness within the last 6 months prior to screening * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Have an estimated glomerular filtration rate (eGFR) \<45 milliliters/minute/1.73 meter squared (mL/min/1.73 m\^2) or lower than the country-specific threshold for discontinuing metformin therapy per local label as determined by the central laboratory * Have a prior or planned surgical treatment for obesity * Have New York Heart Association Functional Classification IV congestive heart failure * Have had an acute myocardial infarction, stroke, or were hospitalized for congestive heart failure within 90 days prior to screening * Have a known clinically significant gastric emptying abnormality * Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years * Have any lifetime history of a suicide attempt * Had chronic or acute pancreatitis * Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia (MEN) syndrome Type 2 * Have taken prescribed or over-the-counter medication, or alternative remedies, intended to promote body weight reduction within 90 days prior to screening.
Conditions
Interventions
Retatrutide
Administered SC.
DRUGSemaglutide
Administered SC.
DRUGTrial Locations
76 locations currently accepting registrations. Choose a recruiting location below to register your interest.
University of Alabama - Department of Nutrition Sciences
Birmingham, Alabama, United States
Neighborhood Healthcare Institute of Health
Escondido, California, United States
Long Beach Research Institute
Long Beach, California, United States
Valley Clinical Trials, Inc.
Northridge, California, United States
Rancho Cucamonga Clinical Research
Rancho Cucamonga, California, United States
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Arrow Clinical Trials
Daytona Beach, Florida, United States
New Age Medical Research Corporation
Miami, Florida, United States
South Broward Research
Miramar, Florida, United States
Clinical Research of Central Florida
Winter Haven, Florida, United States
Herman Clinical Research
Suwanee, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Pacific Diabetes & Endocrine Center
Honolulu, Hawaii, United States
Rocky Mountain Clinical Research
Idaho Falls, Idaho, United States
Deaconess Clinic - Gateway Health Center
Newburgh, Indiana, United States
IMA Clinical Research Monroe - Armand
Monroe, Louisiana, United States
MedStar Health Research Institute (MedStar Physician Based Research Network)
Hyattsville, Maryland, United States
Brigham and Women's Hospital Diabetes Program
Boston, Massachusetts, United States
NECCR PrimaCare Research
Fall River, Massachusetts, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States
Palm Research Center Tenaya
Las Vegas, Nevada, United States
Palm Research Center Sunset
Las Vegas, Nevada, United States
NYC Research INC
Long Island City, New York, United States
Medication Management
Greensboro, North Carolina, United States
Remington Davis Clinical Research
Columbus, Ohio, United States
Alliance for Multispecialty Research, LLC
Norman, Oklahoma, United States
Central States Research
Tulsa, Oklahoma, United States
The Corvallis Clinic, P.C.
Corvallis, Oregon, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
Velocity Clinical Research, Dallas
Dallas, Texas, United States
Valley Institute of Research - Fort Worth
Fort Worth, Texas, United States
Juno Research
Houston, Texas, United States
Southern Endocrinology Associates
Mesquite, Texas, United States
Consano Clinical Research, LLC
Shavano Park, Texas, United States
Texas Valley Clinical Research
Weslaco, Texas, United States
Medrasa Clinical Research
Wylie, Texas, United States
Central Washington Health Services Association d/b/a Confluence Health
Wenatchee, Washington, United States
IMA Clinical Research West Virginia
Morgantown, West Virginia, United States
CARE - Centro de Alergia y Enfermedades Respiratorias
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Stat Research S.A.
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
CIPREC
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Centro Médico Viamonte
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Mautalen Salud e Investigación
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
CEMEDIAB
C.a.b.a., Ciudad Autónoma De Buenos Aires, Argentina
Instituto Centenario
Caba, Ciudad Autónoma De Buenos Aires, Argentina
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Ciudad Autonoma de Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Centro Medico Privado San Vicente Diabetes
Cordoba, Córdoba, Argentina
CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, Mendoza, Argentina
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, Santa Fe, Argentina
Instituto de Investigaciones Clinicas Rosario
Rosario, Santa Fe, Argentina
Fundación Respirar
Buenos Aires, Argentina
Centro de Investigaciones Metabólicas (CINME)
Ciudad Autónoma de Buenos Aires, Argentina
Centro Diabetológico Dr. Waitman
Córdoba, Argentina
University of Calgary - Clinical Trials Unit
Calgary, Alberta, Canada
Alberta Diabetes Institute
Edmonton, Alberta, Canada
Centricity Research Brampton Endocrinology
Brampton, Ontario, Canada
Aggarwal and Associates Limited
Brampton, Ontario, Canada
Winterberry Research Inc.
Hamilton, Ontario, Canada
The Wharton Medical Clinic Clinical Trials Inc
Hamilton, Ontario, Canada
Hamilton Medical Research Group
Hamilton, Ontario, Canada
Bluewater Clinical Research Group Inc.
Sarnia, Ontario, Canada
Prime Health Clinical Research
Toronto, Ontario, Canada
Maple Leaf Research
Toronto, Ontario, Canada
Private Practice - Dr. Nigel Jagan
Whitby, Ontario, Canada
9109-0126 Quebec Inc.
Montreal, Quebec, Canada
RM Pharma Specialists
Mexico City, Distrito Federal, Mexico
Hospital de Jésus, I.A.P.
Mexico City, Distrito Federal, Mexico
Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
Mexico City, Distrito Federal, Mexico
Diseno y Planeacion en Investigacion Medica
Guadalajara, Jalisco, Mexico
Private Practice - Dr. Arechavaleta Granell Maria del Rosario
Guadalajara, Jalisco, Mexico
Instituto de Diabetes, Obesidad y Nutricion
Cuernavaca, Morelos, Mexico
Cardiolink Clin Trials
Monterrey, Nuevo León, Mexico
Clínica García Flores SC
Monterrey, Nuevo León, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Nuevo León, Mexico
Enclifar Ensayos Clínicos Farmacológicos Sc
Chihuahua, Mexico
Instituto Veracruzano en Investigación Clínica S.C.
Veracruz, Mexico
Advanced Clinical Research, LLC
Bayamón, Puerto Rico
GCM Medical Group, PSC - Hato Rey Site
San Juan, Puerto Rico
Sponsor Information
Lead Sponsor
Eli Lilly and Company
Type: INDUSTRY